Klinefelter syndrome can cause many different complications, like anxiety, depression, low self-esteem, emotional immaturity, impulsiveness, weak bones, heart/blood vessel disease, lung disease, breast cancer, other cancers, infertility, problems with sexual function, metabolic syndrome, autoimmune disorders, dental problems, and autism spectrum disorder. The extra X chromosome can be from the mother or the father and occurs with about the same frequency. People typically have 46 chromosomes in each cell, two of which are the sex chromosomes. Some people are affected only very mildly, while for others it has more … If there happens to be any alteration in the Karyotype can result in abnormal behaviour within the chromosomes and, therefore, causing Klinefelter syndrome. The syndrome is not inherited from the parents. However, early death can result from iatrogenesis (complications arising from medicinal or cultural interventions, like surgeries or extreme rituals). Cause of Klinefelter syndrome However, they are more obedient and helpful as compared to the others. Many males are not diagnosed until puberty or adulthood. It is not known what makes XXY boys and men more prone to psychological problems and aggression. 9. Many boys and men don’t realize they have Klinefelter syndrome. Klinefelter syndrome is a sex chromosome disorder in boys and men that results from the presence of an extra X chromosome in cells. Klinefelter syndrome occurs when a boy is born with one or more extra X chromosomes. In 1959, Klinefelter syndrome was found to be caused by a supernumerary X chromosome in a male. In many cases, it’s only detected if a man with Klinefelter syndrome undergoes fertility tests. Most men with Klinefelter syndrome lead the same sort of lives as everybody else. breast enlargement in men, delayed puberty, flaccid muscles, infertility, low-set ears, osteoporosis, low energy level, reduced sex drive, and; a small penis. The most common symptom of Klinefelter syndrome is infertility, which often isn't noticed until adulthood. Klinefelter syndrome … Most often, all the cells of an individual will have that extra copy of the X chromosome and that is what interferes with male sexual development and causes the features of Klinefelter syndrome. It can also develop when the genetic element splits unevenly in the sperm. Other associated Klinefelter syndrome signs and symptoms can include. Males with Klinefelter syndrome have at least one extra X chromosome (47, XXY). Early recognition and hormonal treatment of the disorder can substantially improve quality of life and prevent serious consequences. See some of the causes of Klinefelter Syndrome according to people who have experience in Klinefelter Syndrome. 2002;61:49–53. Often, symptoms are subtle and subjects do not realize they are affected. Normally, males have the XY sex chromosome, determining them of their sex. Clin Genet. Symptoms & causes; Diagnosis & treatment; Doctors & departments; Print. When you can get a whole picture portraying the person's chromosomes, that is called Karyotype. Klinefelter's syndrome is the most common genetic cause of human male infertility, but many cases remain undiagnosed because of substantial variation in clinical presentation and insufficient professional awareness of the syndrome itself. Klinefelter Syndrome Symptoms. This results in a sperm … What causes Klinefelter’s syndrome? Klinefelter syndrome (KS), also known as XXY syndrome, is a genetic cause of male infertility.Children born with this genetic disease have an extra X chromosome, hence the name. Klinefelter syndrome is one of the leading causes of male infertility. Klinefelter Syndrome Karyotype. If there happens to be any alteration in the Karyotype can result in abnormal behaviour within the chromosomes and, therefore, causing Klinefelter syndrome. Klinefelter syndrome happens when a male is born with an additional X chromosome. Then, Dr. Jacobs and his research team found out that it was due to an extra X chromosome (1). The extra x chromosome is retained at the time of gametogenesis (meiosis 1) due to non-dysfunction. Klinefelter syndrome (KS), likewise known as 47 XXY, or Klinefelter-Reifenstein-Albright syndrome or XXY Syndrome, is a common genetic condition that affects 1 in every 1000 live male births. Their karyotype is 47,XXY.. What are the signs and symptoms of Klinefelter syndrome? Klinefelter Syndrome Causes & risk factors. The effects of having an additional chromosome are abnormalities in the normal development of the body, hypogonadism, and male infertility. Klinefelter syndrome only affects males. Signs and symptoms can vary. Klinefelter syndrome is a genetic disorder that causes males to have an extra X chromosome. Sections for Klinefelter syndrome. Klinefelter's Syndrome (KS) is a sex chromosomal disorder like Turner’s syndrome. Klinefelter syndrome doesn’t usually cause any obvious symptoms early in childhood, and even the later symptoms may be difficult to spot. Klinefelter Syndrome – Life Expectancy. While Klinefelter syndrome is genetic (in that it involves an extra X chromosome), it is not usually hereditary in the conventional sense. World map of Klinefelter Syndrome View more. • In children, muscles are weaker and strength is reduced. It is not clear why this happens. Departments and specialties. As discussed earlier, Klinefelter’s syndrome arises due to an extra X chromosome. Klinefelter syndrome was originally described by Dr. Klinefelter back in 1942. Causes Of Klinefelter Syndrome. As many as two-thirds of men with the syndrome may never be diagnosed. This order is so if we go throughout, just due process over one of elimination. As they grow older, they develop into less confident, less active, and shy individuals, who find it difficult to cope up with or fit in with children their age. The symptoms of this condition which impedes cognitive and physical development vary from one affected person to another. Staff skilled in dozens of specialties work together to ensure quality care and successful recovery. The condition is primarily caused by the genetic mutation or the acquisition of male born babies of an extra X sex chromosome. 3.1 Physical Symptoms. • The children who are suffering from this syndrome tend to become taller than average. The existence of an extra X chromosome takes place when the genetic element splits unevenly in the egg. Klinefelter Syndrome often referred to as XXY trisomy, XXY syndrome, and Klinefelter’s Syndrome is a chromosomal disorder exclusively associated with males having one or more of the X chromosome than the normal ‘XY’ pattern. 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